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KMID : 0616619980040010049
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Journal of Soonchunhyang Medical College
1998 Volume.4 No. 1 p.49 ~ p.55
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The Changes of Lipid Profiles according to Administration Method of Progestogen during Hormone Replacement Therapy in Postmenopausal Women
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Abstract
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Objective : The purpose of our study is to evaluate the effect of different administration method of progestogen on lipid profiles including total cholesterol, LDL(low density lipoprotein)-cholesterol, HDL(high density lipoprotein)-cholesterol, triglycerides during hormone replacement therapy in postmenopausal women.
Methods and Materials : Seventy-one postmenopausal women who were assigned to following groups (Group I : conjugated equine estrogen(CEE), 0.625 mg/day plus continuous medroxyprogesterone acetate (MPA), 2.5mg/day, Group II : CEE, 0.625 mg/day plus cyclic MPA, 5mg/day for 12days/month. And we measured serum total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, and triglycerides before hormone replacement therapy(HRT) and 12 months later after hormone replacement therapy.
Results:
1. Total cholesterol decreased in group I,III.
2. HDL-cholesterol increased in group I,II,III.
3. LDL-cholesterol decrease in group I,II.
4. Triglycerides increased in group I,II,III.
There was significance in serum total cholesterol and LDL-cholestrerol among three groups.
Conclusions : Estrogen alone or in combination with progestogen both in cyclic and continuous use improves lipid profiles, so medroxyprogesterone acetate(MPA) does not seem to blunt estrogenic effect on lipid profiles.
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